Coriaria angustissima (400 grm.).

First extract measured 862 c.c. (No. 216) 38 c.c. per kilo: very severe symptoms; recovered. Assuming from previous experiments that the dose here was 7·5 mlgrm., the extract may be said to have contained 0·17 grm. tutin.

Second extract measured 862 grm (No. 211) 40 c.c. per kilo: slight symptoms; recovered. (No. 218) 50 c.c. per kilo: more marked symptoms.

The symptoms observed here corresponded to those produced by a dose of about 5 mlgrm. pure tutin, and on that basis the extract would contain 0·107 grm. tutin. The total in 400 grm. leaf would therefore be 0·277 grm., or a percentage of 0·069; but owing to pressure of other work the lethal doses of the extracts of this variety were not so exactly determined as for C. ruscifolia.

These experiments, so far as they go, indicate that there is little difference between the actual amounts of tutin present in the two varieties.