Toxicity of the Seed.

After trying the hypodermic injection of solutions obtained by various methods of extracting the tutin, the conclusion was arrived at that oral administration of the seed would be the best in this case, as it resembled more closely the natural way in which poisoning might occur. Accordingly, since rabbits could not be induced to swallow the amount of seed required, a watery extract containing suspended matter was made by grinding the dose of seed in a coffee-mill, adding successive small quantities of water, and straining the extracts through cheesecloth. In this way the pulverizable part of the seed was separated from the husk, and a muddy-looking suspension was obtained which could be administered to the rabbit by stomach-tube. The residue left on the straining-cloth was considerable; in several cases where it was collected and dried it